Piperidine-4-thiocarboxamide, N1-BOC protected

Piperidine-4-thiocarboxamide, N1-BOC protected - Names and Identifiers

Name	tert-butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate
Synonyms	N-BOC-piperidine-4-carbothioamide N1-BOC-PIPERIDINE-4-THIOCARBOXAMIDE PIPERIDINE-4-THIOCARBOXAMIDE, 1-BOC PROTECTED Piperidine-4-thiocarboxamide, N1-BOC protected 1-tert-Butoxycarbonylpiperidine-4-carbothioamide tert-butyl 4-(aminocarbothioyl)tetrahydropyridine- tert-butyl 4-carbamothioylpiperidine-1-carboxylate TERT-BUTYL 4-(AMINOCARBOTHIOYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE tert-butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate
CAS	214834-18-1

Piperidine-4-thiocarboxamide, N1-BOC protected - Physico-chemical Properties

Molecular Formula	C11H20N2O2S
Molar Mass	244.35
Density	1.158±0.06 g/cm3(Predicted)
Melting Point	130 °C
Boling Point	356.0±52.0 °C(Predicted)
pKa	13.03±0.20(Predicted)
Storage Condition	2-8°C

Piperidine-4-thiocarboxamide, N1-BOC protected - Risk and Safety

Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed R50 - Very Toxic to aquatic organisms
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
Hazard Note	Irritant

Piperidine-4-thiocarboxamide, N1-BOC protected - Introduction

tert-butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate, also known as tert-butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate, is an organic compound.

Nature:
-Appearance: White to light yellow crystalline solid
-Molecular formula: C11H19N2O2S
-Molecular weight: 237.35g/mol
-Melting point: approximately 80-82 ° C
-Soluble: Soluble in organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane

Use:
- tert-butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate is often used as an important intermediate in organic synthesis reactions
-It can be used to prepare biologically active compounds
-Due to its unique structure, it can be used as a key intermediate for the synthesis of drugs and pesticides

Method:
The preparation method of tert-butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate is relatively simple. A common synthetic method is the reaction of 4-aminotetrahydropyridine with a thiocarbonyl chloride (such as thionyl chloride) to give 4-aminothiocarbonyltetrahydropyridine. It is then reacted with tert-Butyl formate (tert-butyl formate) to give the final product.

Safety Information:
tert-butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate has high safety, but the following points still need to be noted:
-Contact with skin, eyes and respiratory tract should be avoided. Use should wear protective gloves and protective glasses.
-Avoid dust and splash during operation.
-Operate in a well-ventilated place to avoid inhaling volatile gases.
-If accidentally touched or ingested, rinse immediately with water and seek medical help.

Please note that chemical experiments and operations should be carried out under the guidance of professionals and strictly follow safe operating procedures.

Last Update：2024-04-09 15:17:55